Research Guide · Cellular Aging
NAD+
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell and one of the central molecules in aging biology research. Strictly speaking it is not a peptide, but it sits at the center of the mitochondrial research that our peptide line supports.
NAD+ 500mg is listed with our other lyophilized research vials.
← All research guidesWhat NAD+ does in the cell
NAD+ has two broad jobs. First, it shuttles electrons in metabolism: it cycles between NAD+ and NADH in glycolysis, the citric acid cycle and mitochondrial energy production. Second, it is consumed as a substrate by several enzyme families that matter in aging research.
- Sirtuins: NAD+-dependent deacylase enzymes linked to metabolic regulation and studied extensively in aging models.
- PARPs: enzymes that use NAD+ during DNA-damage repair.
- CD38: an NAD+-degrading enzyme whose activity has been reported to rise with age in animal tissues.
NAD+ and aging research
A consistent finding across many rodent studies is that tissue NAD+ levels fall with age. That observation launched a large body of research on restoring NAD+, mostly through precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), and on how NAD+ decline relates to mitochondrial function. Human data is still emerging and results have been mixed, so it remains an active research question rather than a settled one.
Working with an NAD+ research vial
- Quantity: NAD+ is supplied in far larger amounts than peptides; our vial holds 500mg of lyophilized powder.
- Stability: NAD+ is sensitive to heat, light and moisture; store sealed, cold and dark.
- Testing: review the analytical report before use. See how to read a COA.
Related mitochondrial research compounds
Researchers studying NAD+ metabolism often look at related compounds: MOTS-c, a peptide encoded in mitochondrial DNA; SS-31, a peptide that targets the inner mitochondrial membrane; and 5-Amino-1MQ, a small molecule studied as an inhibitor of NNMT, an enzyme in the NAD+ salvage pathway.
Quick facts
- Full name: nicotinamide adenine dinucleotide
- Type: coenzyme (dinucleotide), not a peptide
- Key enzymes: sirtuins, PARPs, CD38
- Ageless vial: 500mg, lyophilized
Shop the research compounds
Lyophilized vial · $59.99MOTS-c 10mg
Mitochondrial peptide · $49.99SS-31 10mg
Mitochondria-targeted peptide · $59.995-Amino-1MQ 50mg
NNMT research · $49.99
Related research guides
Research use only. All Ageless products are sold strictly for in vitro and laboratory research by qualified researchers 21+. They are not drugs, supplements, or cosmetics, and are not for human or veterinary use. Nothing on this page is medical advice or a claim of safety or efficacy in people.
