Mitochondrial

Mitochondrial Pathway Research

Two compounds here approach mitochondrial function from opposite directions — one as a signaling molecule encoded by the mitochondrial genome itself, the other as a structural agent acting on the inner membrane.

• MOTS-c — a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. It is one of a small set of peptides transcribed from the mitochondrial rather than nuclear genome, and is studied in retrograde signaling, AMPK activation and metabolic homeostasis models.
• SS-31 (elamipretide) — a cell-permeable tetrapeptide that associates with cardiolipin, a phospholipid concentrated in the inner mitochondrial membrane. Research interest centers on cristae architecture, electron transport chain efficiency and reactive oxygen species output.

Related Areas

Mitochondrial biogenesis is also investigated through ERR agonism — see SLU-PP-332 under Metabolic Research — and through NAD availability, covered under Cellular Aging Research.

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