Description
MOTS-c is a mitochondrial-derived peptide. It is encoded by the mitochondria’s own DNA rather than the cell nucleus. Each vial contains 10mg of lyophilized MOTS-c for laboratory research.
What Is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded within the 12S rRNA region of mitochondrial DNA. Its description in 2015 helped establish mitochondrial-derived peptides as a research category, showing that mitochondria can produce signaling molecules that act on the rest of the cell.
Published research has linked MOTS-c to AMPK activation and to the folate–methionine cycle, with much of the work in skeletal muscle. Mouse studies have examined MOTS-c in diet-induced metabolic models, and glucose handling, and researchers have reported that it can move to the nucleus under metabolic stress.
Areas of Research Interest
- AMPK activation and cellular energy sensing
- Skeletal-muscle glucose uptake models
- Diet-induced metabolic dysfunction in mice
- Mitochondrial–nuclear signaling
- Age-related metabolic research
Product Specifications
- Compound: MOTS-c (mitochondrial open reading frame of the 12S rRNA-c)
- Contents: 10mg per vial
- Form: Lyophilized powder
- Intended use: Laboratory research only
Handling & Storage
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store according to the label, protected from heat, light and moisture.
Frequently Asked Questions
What does mitochondrial-derived peptide mean?
It means the peptide is encoded within mitochondrial DNA rather than the nuclear genome. MOTS-c is transcribed from an open reading frame in the 12S rRNA region, placing it in a small group of peptides with that origin.
What is retrograde signaling?
It describes communication running from the mitochondria back to the nucleus, influencing nuclear gene expression. MOTS-c is studied as one mediator of that direction of signaling, which is the reverse of the more familiar nucleus-to-mitochondria control.
How is MOTS-c different from SS-31?
Both are studied in mitochondrial research, but they work differently. MOTS-c is a signaling peptide encoded by mitochondrial DNA. SS-31 is a synthetic peptide that binds cardiolipin in the inner mitochondrial membrane.
How is MOTS-c supplied?
As a lyophilized powder in a sealed 10mg vial, for laboratory research use.
Is MOTS-c 10mg Vial intended for human use?
No. This product is sold strictly for in vitro and laboratory research by qualified professionals. It is not for human or veterinary use.
Related Research Compounds
Sold for research purposes only. Not intended for human consumption. These statements have not been evaluated by the FDA. This product is not a drug, food, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease.
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