Description
SLU-PP-332 is a synthetic compound that activates estrogen-related receptors (ERRs), a family of proteins that regulate mitochondrial and energy-metabolism genes. Each vial contains 10mg of lyophilized SLU-PP-332 for laboratory research.
What Is SLU-PP-332?
Despite the name, estrogen-related receptors do not bind estrogen. ERRα, ERRβ, and ERRγ are orphan nuclear receptors that control genes involved in mitochondrial biogenesis, fatty-acid oxidation, and oxidative metabolism. They are especially active in energy-demanding tissue such as skeletal muscle and heart.
SLU-PP-332 was developed as a pan-ERR agonist, with its strongest activity at ERRα. In published mouse studies it increased the expression of genes normally switched on by endurance exercise, which led researchers to describe it as an exercise mimetic. Work to date has been preclinical. SLU-PP-332 is a small molecule, not a peptide.
Areas of Research Interest
- Estrogen-related receptor (ERRα/β/γ) activation
- Mitochondrial biogenesis and oxidative-fiber gene expression
- Fatty-acid oxidation and energy expenditure in mice
- Exercise-mimetic pathway studies
- Comparative work with AMPK-pathway compounds such as MOTS-c
Product Specifications
- Compound: SLU-PP-332 (synthetic ERR agonist)
- Contents: 10mg per vial
- Form: Lyophilized powder
- Intended use: Laboratory research only
Handling & Storage
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store according to the label, protected from heat, light and moisture.
Frequently Asked Questions
What are estrogen-related receptors?
ERRs are orphan nuclear receptors — ERRα, ERRβ and ERRγ — that regulate genes involved in mitochondrial biogenesis and oxidative metabolism. Despite the name they do not bind estrogen; the name reflects sequence similarity to estrogen receptors.
Why is SLU-PP-332 described as an exercise mimetic in the literature?
Because the transcriptional program it activates in published models overlaps with the one endurance exercise induces. The term describes a pattern of gene expression observed in research models, not a demonstrated equivalence.
Does SLU-PP-332 act on estrogen receptors?
No. Estrogen-related receptors are a separate family that share structural similarity with estrogen receptors but do not respond to estrogen.
What compounds are studied alongside it?
Mitochondrial and metabolic labs often compare it with MOTS-c, which is studied through the AMPK pathway, and SS-31.
Is SLU-PP-332 10mg Vial intended for human use?
No. This product is sold strictly for in vitro and laboratory research by qualified professionals. It is not for human or veterinary use.
Related Research Compounds
Sold for research purposes only. Not intended for human consumption. These statements have not been evaluated by the FDA. This product is not a drug, food, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease.
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