Description
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme of growing interest in metabolic research. Each vial contains 50mg of lyophilized 5-Amino-1MQ for laboratory use.
What Is 5-Amino-1MQ?
NNMT transfers a methyl group to nicotinamide, a form of vitamin B3 and a precursor in the NAD+ salvage pathway. NNMT is highly expressed in adipose tissue, and researchers have proposed that elevated NNMT activity diverts nicotinamide and methyl groups away from other cellular processes.
5-Amino-1MQ is a membrane-permeable quinolinium compound designed to selectively inhibit NNMT. In published mouse studies, NNMT inhibition with this class of compound was associated with changes in adipocyte metabolism and cellular NAD+ levels. Note that 5-Amino-1MQ is a small molecule, not a peptide.
Areas of Research Interest
- NNMT enzyme inhibition studies
- Adipocyte differentiation and lipogenesis models
- NAD+ salvage pathway research
- NNMT expression in adipose-derived cell models
- Methyl-donor (SAM) metabolism
Product Specifications
- Compound: 5-Amino-1MQ (5-amino-1-methylquinolinium)
- Contents: 50mg per vial
- Form: Lyophilized powder
- Intended use: Laboratory research only
Handling & Storage
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store according to the label, protected from heat, light and moisture.
5-Amino-1MQ Research Background
5-Amino-1MQ (5-amino-1-methylquinolinium) was characterized by researchers at the University of Texas Medical Branch as a selective, membrane-permeable inhibitor of NNMT. Their foundational study (Neelakantan et al., Biochemical Pharmacology, 2018) examined NNMT inhibition in mouse models of diet-induced obesity. Later work from the same group examined NNMT inhibition alongside diet changes and in aged-muscle models. No human clinical trials have been published.
Why a 50mg Vial?
Many research suppliers sell 5-Amino-1MQ in 5mg or 10mg vials. Each Ageless vial holds 50mg, about $1 per mg at the single-vial price of $49.99, so longer studies need fewer vials. For multi-vial work, the 5-Amino-1MQ Trio bundles three vials at buy 2, get 1 free pricing. Orders ship within 24 hours, with free US shipping over $75.
Frequently Asked Questions
What does NNMT do?
Nicotinamide N-methyltransferase methylates nicotinamide, diverting it away from the NAD salvage pathway. Inhibiting it is studied as a way to alter intracellular NAD availability, particularly in adipose tissue where the enzyme is highly expressed.
What does the quinolinium structure mean for handling?
5-Amino-1MQ is 5-amino-1-methylquinolinium, a small heterocyclic cation. The permanent positive charge on the quinolinium ring is central to how it interacts with the NNMT active site, and it also governs the compound solubility behavior — which differs from the lyophilized peptides elsewhere in the catalog.
Is 5-Amino-1MQ a peptide?
No. It is a small organic molecule. It is often grouped with peptides because it shows up in the same metabolic and cellular-aging research.
How does it relate to NAD+?
NNMT consumes nicotinamide, which cells use to make NAD+. Many labs study 5-Amino-1MQ alongside NAD+ for that reason.
Is 5-Amino-1MQ 50mg Vial intended for human use?
No. This product is sold strictly for in vitro and laboratory research by qualified professionals. It is not for human or veterinary use.
What is the full chemical name of 5-Amino-1MQ?
5-Amino-1MQ is short for 5-amino-1-methylquinolinium. Published literature also abbreviates it as 5A1MQ.
How should a 5-Amino-1MQ vial be stored?
Keep the lyophilized vial sealed, protected from light, and frozen at -20°C for long-term storage. Avoid repeated freeze-thaw cycles.
Where does Ageless Peptides ship 5-Amino-1MQ?
Orders ship within the United States within 24 hours. Shipping is $9.95, or free on orders over $75.
Related Research Compounds
Sold for research purposes only. Not intended for human consumption. These statements have not been evaluated by the FDA. This product is not a drug, food, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease.
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