Description
HCG (human chorionic gonadotropin) is a glycoprotein hormone made up of an alpha subunit shared with LH, FSH and TSH, and a beta subunit unique to hCG. That structural overlap is why it binds and activates the LH/CG receptor, and why it is used as an LH analog in endocrine research models.
Supplied as 5000mcg of lyophilized powder in a sealed vial. Because it is a glycoprotein rather than a short synthetic peptide, handling differs from most of the catalog — it is more sensitive to agitation and repeated freeze-thaw cycles, and reconstituted material has a shorter working window.
What Is HCG?
HCG is made of two subunits. The alpha subunit is shared with luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). The beta subunit is unique to HCG and gives it its receptor specificity and long half-life. HCG and LH both bind the same receptor, the LH/choriogonadotropin receptor (LHCGR).
Because it activates the LHCGR potently and lasts longer than LH, HCG is a standard tool for studying how gonadal cells respond to gonadotropin signaling. Laboratory models include Leydig-cell testosterone synthesis, ovarian theca and granulosa cell research, and investigations of the hypothalamic-pituitary-gonadal (HPG) axis.
Areas of Research Interest
- LH/CG receptor (LHCGR) signaling
- Leydig-cell steroidogenesis models
- Ovarian theca and granulosa cell research
- Hypothalamic-pituitary-gonadal axis studies
- Glycoprotein hormone structure and subunit research
Product Specifications
- Compound: HCG (human chorionic gonadotropin)
- Contents: 5000mcg per vial
- Form: Lyophilized powder
- Intended use: Laboratory research only
Handling & Storage
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store according to the label, protected from heat, light and moisture.
Frequently Asked Questions
What are the alpha and beta subunits?
hCG is a heterodimer. Its alpha subunit is shared with LH, FSH and TSH; its beta subunit is unique to hCG and determines receptor specificity. The two are non-covalently associated, which is part of why the molecule is sensitive to agitation.
Why is hCG quantified in IU as well as micrograms?
Because glycosylation varies between preparations, hCG was historically quantified by bioactivity in international units rather than by mass. Research material is often labeled both ways, and the conversion between them depends on the specific preparation.
Is HCG a peptide?
HCG is a glycoprotein, a much larger protein with attached sugar chains, rather than a short peptide. It is supplied lyophilized like our peptide vials.
Why does HCG act like LH in research models?
HCG and LH share an alpha subunit and bind the same receptor, the LHCGR. HCG’s beta subunit gives it a longer half-life.
Is HCG 5000mcg Vial intended for human use?
No. This product is sold strictly for in vitro and laboratory research by qualified professionals. It is not for human or veterinary use.
Related Research Compounds
Sold for research purposes only. Not intended for human consumption. These statements have not been evaluated by the FDA. This product is not a drug, food, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease.
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