Description
KPV is a three-amino-acid peptide (lysine-proline-valine) derived from the tail end of alpha-melanocyte-stimulating hormone. Each vial contains 10mg of lyophilized KPV for laboratory research.
What Is KPV?
Alpha-MSH is a 13-amino-acid hormone with well-documented anti-inflammatory signaling in laboratory models. KPV corresponds to its final three amino acids (positions 11–13), and researchers have studied it as a much smaller fragment that retains part of that signaling activity, largely without alpha-MSH’s pigmentation effects.
Published KPV research has focused heavily on intestinal inflammation models in mice and on cell studies of NF-κB, a central inflammatory signaling pathway. Some work has examined uptake through PepT1, a peptide transporter found in the intestinal lining, as well as KPV’s behavior in skin and epithelial cell models.
Areas of Research Interest
- NF-κB and inflammatory cytokine signaling in cell models
- Murine models of intestinal inflammation
- PepT1-mediated peptide transport
- Epithelial and keratinocyte cell research
- Comparative work with full-length alpha-MSH
Product Specifications
- Compound: KPV (Lys-Pro-Val tripeptide)
- Contents: 10mg per vial
- Form: Lyophilized powder
- Intended use: Laboratory research only
Handling & Storage
Supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store according to the label, protected from heat, light and moisture.
Frequently Asked Questions
Why use KPV rather than full-length alpha-MSH?
Alpha-MSH activates melanocortin receptors, producing pigmentation activity alongside its other effects. KPV is the C-terminal tripeptide and carries the anti-inflammatory arm without that receptor-mediated pigmentation response, which isolates one mechanism from the other.
Which models is KPV most often used in?
Intestinal epithelial cell culture and cytokine expression assays account for most published work, with NF-κB pathway activity and tight-junction integrity as common endpoints.
How is KPV related to Melanotan 2?
Both trace back to alpha-MSH. Melanotan 2 is a synthetic analog of the whole hormone studied at melanocortin receptors, while KPV is only its last three amino acids.
Is KPV available in a blend?
Yes. KPV is the fourth component of the KLOW Blend 80mg, alongside GHK-Cu, BPC-157, and TB-500.
Is KPV 10mg Vial intended for human use?
No. This product is sold strictly for in vitro and laboratory research by qualified professionals. It is not for human or veterinary use.
Related Research Compounds
Sold for research purposes only. Not intended for human consumption. These statements have not been evaluated by the FDA. This product is not a drug, food, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease.
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