Cosmetic

Melanogenesis and MC1R Research
Pigmentation research centers on the melanocortin 1 receptor (MC1R), expressed on melanocytes, and the downstream cAMP signaling that drives the switch from pheomelanin to eumelanin synthesis. Melanotan 2 is a cyclic synthetic analog of alpha-melanocyte stimulating hormone (α-MSH) and is the compound most commonly used in this model work.
Unlike α-MSH itself, Melanotan 2 is non-selective across the melanocortin receptors, so researchers isolating MC1R activity need to control for activity at MC3R, MC4R and MC5R — receptors covered under Melanocortin & Endocrine Research. Its cyclic structure also makes it considerably more stable than the linear native peptide, which is why it appears so often in place of α-MSH in published protocols.
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